Buprenorphine-naloxone is a generic formulation, while Suboxone is a brand name for the same medication. 

Both buprenorphine-naloxone and Suboxone contain buprenorphine, an opioid partial agonist, and naloxone, an opioid antagonist. 

They are used in medication-assisted treatment (MAT) for opioid use disorder (OUD). 

The inclusion of naloxone in the formulation helps deter misuse by causing withdrawal symptoms if injected. 

Both medications work to reduce cravings and withdrawal symptoms without inducing the same euphoria as full opioids. 

Suboxone, being a brand name, might have slight variations in inactive ingredients compared to generic buprenorphine-naloxone. 

Patients transitioning from opioids to buprenorphine-naloxone or Suboxone must be in mild to moderate withdrawal to avoid precipitating severe withdrawal symptoms. 

These medications are administered sublingually (under the tongue) in the form of dissolvable films or tablets. 

The choice between buprenorphine-naloxone and Suboxone may depend on insurance coverage, cost, and individual preferences. 

Both buprenorphine-naloxone and Suboxone are effective components of comprehensive treatment programs for opioid addiction.